
Senior Accountant
natera • US Remote
Posted: August 24, 2026
Job Description
Senior Accountant
Clinical Trials & R&D | Finance | Remote (US)
POSITION SUMMARY
Natera is seeking an experienced and detail-oriented Senior Accountant to support key accounting operations related to Clinical Trials and Research & Development (R&D) activities. This role is responsible for clinical trial accruals, prepaid expense accounting, R&D expense analysis, month-end close activities, and financial reporting in compliance with GAAP, ASC 730, and SOX requirements.
The Senior Accountant will partner closely with Clinical Operations, FP&A, Procurement, and external vendors including CROs and clinical sites to ensure accurate accounting and reporting of clinical trial and R&D expenditures. This individual will also support process improvements and technical accounting reviews related to clinical trial agreements and research activities.
This is a fully remote position, offering the opportunity to work from anywhere within the United States while collaborating with a high-performing and dynamic finance team. It is an excellent opportunity for an accounting professional looking to grow within a rapidly expanding public biotechnology company.
KEY RESPONSIBILITIES
Clinical Trial & R&D Accounting
- Prepare monthly clinical trial accruals, prepaid roll-forwards, and reconciliations in accordance with ASC 730
- Gather enrollment, site activity, and milestone data from Clinical Operations to support accrual calculations
- Review CRO and clinical site invoices against contracted milestones and fee schedules; identify and investigate variances
- Support R&D expense accounting, including accruals, prepaid amortization, and cost allocations
- Assist with technical accounting reviews of new and amended clinical trial agreements
- Maintain supporting schedules and documentation related to clinical trial and R&D accounting activities
- Partner cross-functionally with Clinical Operations, Legal, Procurement, and FP&A to ensure accurate and timely accounting treatment of research-related expenditures
Month-End Close & Financial Reporting
- Perform month-end close activities, including journal entries, account reconciliations, and flux analysis
- Prepare fluctuation analyses and provide explanations for financial trends and variances
- Review, investigate, and correct accounting errors, inconsistencies, and reporting issues
- Ensure compliance with GAAP, internal controls, and company accounting policies
- Proactively communicate accounting, financial reporting, or control issues to management
- Support internal and external audit requests, including preparation of supporting documentation
SOX Compliance & Process Improvement
- Execute SOX 404(b) controls related to clinical trial and R&D accounting processes
- Contribute to process improvements across clinical trial and R&D accounting workflows
- Participate in automation, scalability, and operational efficiency initiatives within the accounting function
- Collaborate with team members to improve reporting accuracy and streamline month-end close processes
KEY QUALIFICATIONS
Experience & Background
- Minimum of 2–3 years of accounting or audit experience required
- Public accounting/audit background required; Big 4 experience strongly preferred given SOX and technical accounting scope
- Experience in biotechnology, life sciences, healthcare, or pharmaceutical industries strongly preferred
- Experience supporting R&D or clinical trial accounting activities preferred
Competencies
- Proven ability to perform under pressure and consistently meet tight deadlines
- Highly proactive self-starter with strong ownership mindset and ability to work independently
- Quick learner who can ramp up on new systems, processes, and technical topics with minimal guidance
- Demonstrated track record of identifying and implementing process improvements
- Ability to navigate ambiguity and adapt quickly in a fast-paced environment
- Strong analytical, organizational, and problem-solving skills
- Excellent verbal and written communication skills; detail-oriented with a high degree of accuracy and accountability
- Team-oriented mindset with a willingness to learn and take initiative
EDUCATION & CERTIFICATIONS
- Bachelor's Degree in Accounting, Finance, or related field required; equivalent combination of education and experience may be considered
- CPA: Preferred, not required
TECHNICAL SKILLS
- Advanced Excel: Required (complex formulas, pivot tables, financial modeling)
- Oracle Fusion ERP: Preferred
- Google Workspace: Preferred (Gmail, Google Sheets, Google Docs)
- Strong understanding of accrual accounting and GAAP, including ASC 730 R&D accounting
- Experience with clinical trial accounting, CRO/vendor management, or life sciences accounting processes preferred
Additional Content
Senior Accountant
Clinical Trials & R&D | Finance | Remote (US)
POSITION SUMMARY
Natera is seeking an experienced and detail-oriented Senior Accountant to support key accounting operations related to Clinical Trials and Research & Development (R&D) activities. This role is responsible for clinical trial accruals, prepaid expense accounting, R&D expense analysis, month-end close activities, and financial reporting in compliance with GAAP, ASC 730, and SOX requirements.
The Senior Accountant will partner closely with Clinical Operations, FP&A, Procurement, and external vendors including CROs and clinical sites to ensure accurate accounting and reporting of clinical trial and R&D expenditures. This individual will also support process improvements and technical accounting reviews related to clinical trial agreements and research activities.
This is a fully remote position, offering the opportunity to work from anywhere within the United States while collaborating with a high-performing and dynamic finance team. It is an excellent opportunity for an accounting professional looking to grow within a rapidly expanding public biotechnology company.
KEY RESPONSIBILITIES
Clinical Trial & R&D Accounting
- Prepare monthly clinical trial accruals, prepaid roll-forwards, and reconciliations in accordance with ASC 730
- Gather enrollment, site activity, and milestone data from Clinical Operations to support accrual calculations
- Review CRO and clinical site invoices against contracted milestones and fee schedules; identify and investigate variances
- Support R&D expense accounting, including accruals, prepaid amortization, and cost allocations
- Assist with technical accounting reviews of new and amended clinical trial agreements
- Maintain supporting schedules and documentation related to clinical trial and R&D accounting activities
- Partner cross-functionally with Clinical Operations, Legal, Procurement, and FP&A to ensure accurate and timely accounting treatment of research-related expenditures
Month-End Close & Financial Reporting
- Perform month-end close activities, including journal entries, account reconciliations, and flux analysis
- Prepare fluctuation analyses and provide explanations for financial trends and variances
- Review, investigate, and correct accounting errors, inconsistencies, and reporting issues
- Ensure compliance with GAAP, internal controls, and company accounting policies
- Proactively communicate accounting, financial reporting, or control issues to management
- Support internal and external audit requests, including preparation of supporting documentation
SOX Compliance & Process Improvement
- Execute SOX 404(b) controls related to clinical trial and R&D accounting processes
- Contribute to process improvements across clinical trial and R&D accounting workflows
- Participate in automation, scalability, and operational efficiency initiatives within the accounting function
- Collaborate with team members to improve reporting accuracy and streamline month-end close processes
KEY QUALIFICATIONS
Experience & Background
- Minimum of 2–3 years of accounting or audit experience required
- Public accounting/audit background required; Big 4 experience strongly preferred given SOX and technical accounting scope
- Experience in biotechnology, life sciences, healthcare, or pharmaceutical industries strongly preferred
- Experience supporting R&D or clinical trial accounting activities preferred
Competencies
- Proven ability to perform under pressure and consistently meet tight deadlines
- Highly proactive self-starter with strong ownership mindset and ability to work independently
- Quick learner who can ramp up on new systems, processes, and technical topics with minimal guidance
- Demonstrated track record of identifying and implementing process improvements
- Ability to navigate ambiguity and adapt quickly in a fast-paced environment
- Strong analytical, organizational, and problem-solving skills
- Excellent verbal and written communication skills; detail-oriented with a high degree of accuracy and accountability
- Team-oriented mindset with a willingness to learn and take initiative
EDUCATION & CERTIFICATIONS
- Bachelor's Degree in Accounting, Finance, or related field required; equivalent combination of education and experience may be considered
- CPA: Preferred, not required
TECHNICAL SKILLS
- Advanced Excel: Required (complex formulas, pivot tables, financial modeling)
- Oracle Fusion ERP: Preferred
- Google Workspace: Preferred (Gmail, Google Sheets, Google Docs)
- Strong understanding of accrual accounting and GAAP, including ASC 730 R&D accounting
- Experience with clinical trial accounting, CRO/vendor management, or life sciences accounting processes preferred