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Senior Accountant

natera US Remote


No Relocation

Posted: August 24, 2026

Job Description

Senior Accountant

Clinical Trials & R&D | Finance | Remote (US)

POSITION SUMMARY

Natera is seeking an experienced and detail-oriented Senior Accountant to support key accounting operations related to Clinical Trials and Research & Development (R&D) activities. This role is responsible for clinical trial accruals, prepaid expense accounting, R&D expense analysis, month-end close activities, and financial reporting in compliance with GAAP, ASC 730, and SOX requirements.

The Senior Accountant will partner closely with Clinical Operations, FP&A, Procurement, and external vendors including CROs and clinical sites to ensure accurate accounting and reporting of clinical trial and R&D expenditures. This individual will also support process improvements and technical accounting reviews related to clinical trial agreements and research activities.

This is a fully remote position, offering the opportunity to work from anywhere within the United States while collaborating with a high-performing and dynamic finance team. It is an excellent opportunity for an accounting professional looking to grow within a rapidly expanding public biotechnology company.

KEY RESPONSIBILITIES

Clinical Trial & R&D Accounting

  • Prepare monthly clinical trial accruals, prepaid roll-forwards, and reconciliations in accordance with ASC 730
  • Gather enrollment, site activity, and milestone data from Clinical Operations to support accrual calculations
  • Review CRO and clinical site invoices against contracted milestones and fee schedules; identify and investigate variances
  • Support R&D expense accounting, including accruals, prepaid amortization, and cost allocations
  • Assist with technical accounting reviews of new and amended clinical trial agreements
  • Maintain supporting schedules and documentation related to clinical trial and R&D accounting activities
  • Partner cross-functionally with Clinical Operations, Legal, Procurement, and FP&A to ensure accurate and timely accounting treatment of research-related expenditures

Month-End Close & Financial Reporting

  • Perform month-end close activities, including journal entries, account reconciliations, and flux analysis
  • Prepare fluctuation analyses and provide explanations for financial trends and variances
  • Review, investigate, and correct accounting errors, inconsistencies, and reporting issues
  • Ensure compliance with GAAP, internal controls, and company accounting policies
  • Proactively communicate accounting, financial reporting, or control issues to management
  • Support internal and external audit requests, including preparation of supporting documentation

SOX Compliance & Process Improvement

  • Execute SOX 404(b) controls related to clinical trial and R&D accounting processes
  • Contribute to process improvements across clinical trial and R&D accounting workflows
  • Participate in automation, scalability, and operational efficiency initiatives within the accounting function
  • Collaborate with team members to improve reporting accuracy and streamline month-end close processes

 

KEY QUALIFICATIONS

Experience & Background

  • Minimum of 2–3 years of accounting or audit experience required
  • Public accounting/audit background required; Big 4 experience strongly preferred given SOX and technical accounting scope
  • Experience in biotechnology, life sciences, healthcare, or pharmaceutical industries strongly preferred
  • Experience supporting R&D or clinical trial accounting activities preferred

Competencies

  • Proven ability to perform under pressure and consistently meet tight deadlines
  • Highly proactive self-starter with strong ownership mindset and ability to work independently
  • Quick learner who can ramp up on new systems, processes, and technical topics with minimal guidance
  • Demonstrated track record of identifying and implementing process improvements
  • Ability to navigate ambiguity and adapt quickly in a fast-paced environment
  • Strong analytical, organizational, and problem-solving skills
  • Excellent verbal and written communication skills; detail-oriented with a high degree of accuracy and accountability
  • Team-oriented mindset with a willingness to learn and take initiative

 

EDUCATION & CERTIFICATIONS

  • Bachelor's Degree in Accounting, Finance, or related field required; equivalent combination of education and experience may be considered
  • CPA: Preferred, not required

 

TECHNICAL SKILLS

  • Advanced Excel: Required (complex formulas, pivot tables, financial modeling)
  • Oracle Fusion ERP: Preferred
  • Google Workspace: Preferred (Gmail, Google Sheets, Google Docs)
  • Strong understanding of accrual accounting and GAAP, including ASC 730 R&D accounting
  • Experience with clinical trial accounting, CRO/vendor management, or life sciences accounting processes preferred

Additional Content

Senior Accountant

Clinical Trials & R&D | Finance | Remote (US)

POSITION SUMMARY

Natera is seeking an experienced and detail-oriented Senior Accountant to support key accounting operations related to Clinical Trials and Research & Development (R&D) activities. This role is responsible for clinical trial accruals, prepaid expense accounting, R&D expense analysis, month-end close activities, and financial reporting in compliance with GAAP, ASC 730, and SOX requirements.

The Senior Accountant will partner closely with Clinical Operations, FP&A, Procurement, and external vendors including CROs and clinical sites to ensure accurate accounting and reporting of clinical trial and R&D expenditures. This individual will also support process improvements and technical accounting reviews related to clinical trial agreements and research activities.

This is a fully remote position, offering the opportunity to work from anywhere within the United States while collaborating with a high-performing and dynamic finance team. It is an excellent opportunity for an accounting professional looking to grow within a rapidly expanding public biotechnology company.

KEY RESPONSIBILITIES

Clinical Trial & R&D Accounting

  • Prepare monthly clinical trial accruals, prepaid roll-forwards, and reconciliations in accordance with ASC 730
  • Gather enrollment, site activity, and milestone data from Clinical Operations to support accrual calculations
  • Review CRO and clinical site invoices against contracted milestones and fee schedules; identify and investigate variances
  • Support R&D expense accounting, including accruals, prepaid amortization, and cost allocations
  • Assist with technical accounting reviews of new and amended clinical trial agreements
  • Maintain supporting schedules and documentation related to clinical trial and R&D accounting activities
  • Partner cross-functionally with Clinical Operations, Legal, Procurement, and FP&A to ensure accurate and timely accounting treatment of research-related expenditures

Month-End Close & Financial Reporting

  • Perform month-end close activities, including journal entries, account reconciliations, and flux analysis
  • Prepare fluctuation analyses and provide explanations for financial trends and variances
  • Review, investigate, and correct accounting errors, inconsistencies, and reporting issues
  • Ensure compliance with GAAP, internal controls, and company accounting policies
  • Proactively communicate accounting, financial reporting, or control issues to management
  • Support internal and external audit requests, including preparation of supporting documentation

SOX Compliance & Process Improvement

  • Execute SOX 404(b) controls related to clinical trial and R&D accounting processes
  • Contribute to process improvements across clinical trial and R&D accounting workflows
  • Participate in automation, scalability, and operational efficiency initiatives within the accounting function
  • Collaborate with team members to improve reporting accuracy and streamline month-end close processes

 

KEY QUALIFICATIONS

Experience & Background

  • Minimum of 2–3 years of accounting or audit experience required
  • Public accounting/audit background required; Big 4 experience strongly preferred given SOX and technical accounting scope
  • Experience in biotechnology, life sciences, healthcare, or pharmaceutical industries strongly preferred
  • Experience supporting R&D or clinical trial accounting activities preferred

Competencies

  • Proven ability to perform under pressure and consistently meet tight deadlines
  • Highly proactive self-starter with strong ownership mindset and ability to work independently
  • Quick learner who can ramp up on new systems, processes, and technical topics with minimal guidance
  • Demonstrated track record of identifying and implementing process improvements
  • Ability to navigate ambiguity and adapt quickly in a fast-paced environment
  • Strong analytical, organizational, and problem-solving skills
  • Excellent verbal and written communication skills; detail-oriented with a high degree of accuracy and accountability
  • Team-oriented mindset with a willingness to learn and take initiative

 

EDUCATION & CERTIFICATIONS

  • Bachelor's Degree in Accounting, Finance, or related field required; equivalent combination of education and experience may be considered
  • CPA: Preferred, not required

 

TECHNICAL SKILLS

  • Advanced Excel: Required (complex formulas, pivot tables, financial modeling)
  • Oracle Fusion ERP: Preferred
  • Google Workspace: Preferred (Gmail, Google Sheets, Google Docs)
  • Strong understanding of accrual accounting and GAAP, including ASC 730 R&D accounting
  • Experience with clinical trial accounting, CRO/vendor management, or life sciences accounting processes preferred