Senior Director, Strategic Portfolio Management

Job Description

• This position is posted by Jobgether on behalf of a partner company. We are currently looking for a Senior Director, Strategic Portfolio Management in the United States. This is a high-impact leadership opportunity for an experienced portfolio management professional to shape and optimize a global R&D pipeline within a dynamic healthcare environment. The role focuses on driving strategic portfolio decisions that balance scientific innovation, financial performance, and long-term business value. Working closely with senior executives and cross-functional teams, the successful candidate will oversee portfolio governance, investment prioritization, scenario planning, and resource allocation across a broad range of development programs. This position offers the opportunity to influence enterprise-level strategy while leading a culture of data-driven decision-making and operational excellence. The role is ideal for professionals who thrive in complex, matrixed organizations and are passionate about advancing healthcare innovation on a global scale. Candidates will play a critical role in aligning scientific ambition with sustainable growth and organizational priorities.
• Accountabilities: Lead enterprise-wide R&D portfolio reviews and annual strategic workplan processes to ensure alignment with corporate goals and therapeutic priorities. Drive portfolio optimization across therapeutic areas, modalities, development stages, and risk profiles to maximize long-term value creation. Provide strategic recommendations through data-driven prioritization, scenario analysis, and investment trade-off evaluations. Support governance forums and executive decision-making processes related to portfolio investments, milestone progression, acceleration, or discontinuation of programs. Integrate scientific, clinical, operational, financial, and commercial insights into portfolio strategy and planning activities. Oversee financial forecasting, capital allocation, headcount planning, and external spending considerations tied to R&D initiatives. Develop and maintain portfolio analytics, dashboards, metrics, and executive-level reporting tools to improve visibility and decision quality. Collaborate cross-functionally with development, regulatory, commercial, finance, manufacturing, and business development teams. Support evaluation of external opportunities including licensing, partnerships, collaborations, and acquisition initiatives. Build and mentor a high-performing strategic portfolio management team while promoting transparency, accountability, and evidence-based decision-making. Requirements: Bachelor’s degree required; advanced degree such as PhD, MD, PharmD, MSc, or MBA strongly preferred. Minimum 15 years of experience within pharmaceutical or biotech R&D environments, including leadership roles in portfolio or program management. Strong expertise in strategic portfolio management, investment governance, and R&D strategy development. Deep understanding of drug development processes, clinical development, and R&D financial modeling. Experience supporting executive leadership teams and contributing to enterprise-level strategic decisions. Strong analytical and financial acumen with the ability to synthesize complex scientific and business data into actionable recommendations. Proven ability to work effectively within highly matrixed and globally distributed organizations. Excellent communication, presentation, negotiation, and stakeholder management skills, including executive and board-level interactions. Strong leadership capabilities with experience building collaborative, high-performing teams. PMP, PgMP, or equivalent program management certification is considered an advantage. Ability to manage complexity, uncertainty, and long development timelines while maintaining strategic focus and operational execution. Benefits: Competitive salary range of $151,000 – $314,000 USD annually. Comprehensive healthcare and wellness benefits package. Retirement savings and financial planning benefits. Remote work flexibility within the United States. Inclusive and collaborative global work environment. Opportunities for leadership growth and career advancement. Exposure to enterprise-level strategic initiatives and executive leadership. Supportive culture focused on innovation, collaboration, and professional development. Opportunity to contribute to healthcare solutions impacting patients worldwide. Diverse and globally connected workplace with strong commitment to inclusion and equal opportunity.
• How Jobgether works: We use an AI-powered matching process to ensure your application is reviewed quickly, objectively, and fairly against the role's core requirements. Our system identifies the top-fitting candidates, and this shortlist is then shared directly with the hiring company. The final decision and next steps (interviews, assessments) are managed by their internal team. We appreciate your interest and wish you the best! Why Apply Through Jobgether? Data Privacy Notice: By submitting your application, you acknowledge that Jobgether will process your personal data to evaluate your candidacy and share relevant information with the hiring employer. This processing is based on legitimate interest and pre-contractual measures under applicable data protection laws (including GDPR). You may exercise your rights (access, rectification, erasure, objection) at any time. #LI-CL1
• We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.
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