Translational IHC (Consultant)
legendcareers • United States
No Relocation
Posted: May 28, 2026
Job Description
Legend Biotech is seeking a Translational IHC Consultant as part of the Early Drug Development team based remotely.
Role Overview
This role bridges pathology, biomarker and clinical development, ensuring high-quality tissue biomarker data generation to inform baseline, compound MoA, target engagement and safety.
Key Responsibilities
- Collaborate with selected CRO to develop, optimize and validate chromogenic IHC, mIF and spatial Omics as well as ensure assays are phase-appropriate and fit-for-purpose (exploratory to clinical and potential CDx pathway). Define technical requirement and quality criteria such as antibody selection and qualification, benchmark and scoring algorithms and support GCP-aligned assay validation whenever applicable. Review study design, validation and analysis reports.
- Partner with TR scientists, clinical development and pathologists to translate biological questions and clinical challenges into quantitative image-based endpoints and computational workflows.
- Interpret data in collaboration with Translational scientists and pathologists. Correlate findings with clinical endpoints and peripheral biomarkers from Flow cytometry, cytokine and Omics data. Provide mechanistic insights in CAR-T infiltration, immune activation and exhaustion and on- and off-target signals.
- Documents image processing workflows in compliance with internal SOPs and collaborate with global teams for training and deliverables.
- Contribute clinical protocols and regulatory submissions and briefing documents.
- Candidate has the authority to make decisions related to methodologies and approaches development processes. He/she can make decisions related to project execution, including timelines and milestones. Higher-level approvals are required for those related to significant technical selection, strategic shifts, or major collaborations that have substantial scientific and long-term implications.
Requirements
- Ph.D in Pathology, Immunology, Oncology or related field.
- 5+ years of experience in Translational biomarker development; IHC/mIF assay development in oncology and immunology.
- Deep understanding of TME, Immune cell phenotyping.
- Deep understanding of image analysis method such as segmentation, detection and classification, etc.
- Experience supporting clinical trials.
- Former biopharma TR/pathology lead preferred
- Proficiency in image analysis platforms such as HALO, VisioPharm, QuPath, etc.
#Li-JR1`
#Li-Remote
Additional Content
Legend Biotech is seeking a Translational IHC Consultant as part of the Early Drug Development team based remotely.
Role Overview
This role bridges pathology, biomarker and clinical development, ensuring high-quality tissue biomarker data generation to inform baseline, compound MoA, target engagement and safety.
Key Responsibilities
- Collaborate with selected CRO to develop, optimize and validate chromogenic IHC, mIF and spatial Omics as well as ensure assays are phase-appropriate and fit-for-purpose (exploratory to clinical and potential CDx pathway). Define technical requirement and quality criteria such as antibody selection and qualification, benchmark and scoring algorithms and support GCP-aligned assay validation whenever applicable. Review study design, validation and analysis reports.
- Partner with TR scientists, clinical development and pathologists to translate biological questions and clinical challenges into quantitative image-based endpoints and computational workflows.
- Interpret data in collaboration with Translational scientists and pathologists. Correlate findings with clinical endpoints and peripheral biomarkers from Flow cytometry, cytokine and Omics data. Provide mechanistic insights in CAR-T infiltration, immune activation and exhaustion and on- and off-target signals.
- Documents image processing workflows in compliance with internal SOPs and collaborate with global teams for training and deliverables.
- Contribute clinical protocols and regulatory submissions and briefing documents.
- Candidate has the authority to make decisions related to methodologies and approaches development processes. He/she can make decisions related to project execution, including timelines and milestones. Higher-level approvals are required for those related to significant technical selection, strategic shifts, or major collaborations that have substantial scientific and long-term implications.
Requirements
- Ph.D in Pathology, Immunology, Oncology or related field.
- 5+ years of experience in Translational biomarker development; IHC/mIF assay development in oncology and immunology.
- Deep understanding of TME, Immune cell phenotyping.
- Deep understanding of image analysis method such as segmentation, detection and classification, etc.
- Experience supporting clinical trials.
- Former biopharma TR/pathology lead preferred
- Proficiency in image analysis platforms such as HALO, VisioPharm, QuPath, etc.
#Li-JR1`
#Li-Remote